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LWDHD formulations inhibit NP cell pyroptosis in IVDD mice. ( A – D ) IF staining and corresponding qualification of <t>CASPASE1</t> ( A and B ), GSDMD ( C and D ) in IVDs of IVDD mice after treatment with LWDHD formulation for 2 weeks. White arrows indicate high expression of CASPASE1 and GSDMD in NP tissues. ( E and F ) IHC staining and corresponding qualification of IL-1β in IVDs of IVDD mice. Black arrows indicate high expression of IL-1β in NP tissues. Data are shown as mean ± SEM (n = 6). *Denotes a significant difference compared with the Sham group (** p < 0.01), # Means a significant difference compared with the Vehicle group ( ## p < 0.01), + Indicates a significant difference compared with the LWDHD group ( + p < 0.05, ++ p < 0.01), & Means a significant difference compared with the 5 × CO group ( && p < 0.01).
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Average 96 stars, based on 1 article reviews
primary antibody against caspase1 - by Bioz Stars, 2026-09
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primary antibodies against cleaved-caspase1 #4199  (Cell Signaling Technology Inc)
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LWDHD formulations inhibit NP cell pyroptosis in IVDD mice. ( A – D ) IF staining and corresponding qualification of <t>CASPASE1</t> ( A and B ), GSDMD ( C and D ) in IVDs of IVDD mice after treatment with LWDHD formulation for 2 weeks. White arrows indicate high expression of CASPASE1 and GSDMD in NP tissues. ( E and F ) IHC staining and corresponding qualification of IL-1β in IVDs of IVDD mice. Black arrows indicate high expression of IL-1β in NP tissues. Data are shown as mean ± SEM (n = 6). *Denotes a significant difference compared with the Sham group (** p < 0.01), # Means a significant difference compared with the Vehicle group ( ## p < 0.01), + Indicates a significant difference compared with the LWDHD group ( + p < 0.05, ++ p < 0.01), & Means a significant difference compared with the 5 × CO group ( && p < 0.01).
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primary antibodies against cleaved-caspase1 #4199 - by Bioz Stars, 2026-09
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LWDHD formulations inhibit NP cell pyroptosis in IVDD mice. ( A – D ) IF staining and corresponding qualification of CASPASE1 ( A and B ), GSDMD ( C and D ) in IVDs of IVDD mice after treatment with LWDHD formulation for 2 weeks. White arrows indicate high expression of CASPASE1 and GSDMD in NP tissues. ( E and F ) IHC staining and corresponding qualification of IL-1β in IVDs of IVDD mice. Black arrows indicate high expression of IL-1β in NP tissues. Data are shown as mean ± SEM (n = 6). *Denotes a significant difference compared with the Sham group (** p < 0.01), # Means a significant difference compared with the Vehicle group ( ## p < 0.01), + Indicates a significant difference compared with the LWDHD group ( + p < 0.05, ++ p < 0.01), & Means a significant difference compared with the 5 × CO group ( && p < 0.01).

Journal: Journal of Inflammation Research

Article Title: Augmented Cornus officinalis Levels in Liuwei Dihuang Decoction Inhibits Nucleus Pulposus Cell Pyroptosis to Enhance Therapeutic Efficacy Against Intervertebral Disc Degeneration

doi: 10.2147/JIR.S465690

Figure Lengend Snippet: LWDHD formulations inhibit NP cell pyroptosis in IVDD mice. ( A – D ) IF staining and corresponding qualification of CASPASE1 ( A and B ), GSDMD ( C and D ) in IVDs of IVDD mice after treatment with LWDHD formulation for 2 weeks. White arrows indicate high expression of CASPASE1 and GSDMD in NP tissues. ( E and F ) IHC staining and corresponding qualification of IL-1β in IVDs of IVDD mice. Black arrows indicate high expression of IL-1β in NP tissues. Data are shown as mean ± SEM (n = 6). *Denotes a significant difference compared with the Sham group (** p < 0.01), # Means a significant difference compared with the Vehicle group ( ## p < 0.01), + Indicates a significant difference compared with the LWDHD group ( + p < 0.05, ++ p < 0.01), & Means a significant difference compared with the 5 × CO group ( && p < 0.01).

Article Snippet: Primary antibody against CASPASE1 was obtained from ProteinTech Group (Chicago, IL, USA).

Techniques: Staining, Formulation, Expressing, Immunohistochemistry

Combined Score of Modified Formulations of LWDHD in Delaying IVDD

Journal: Journal of Inflammation Research

Article Title: Augmented Cornus officinalis Levels in Liuwei Dihuang Decoction Inhibits Nucleus Pulposus Cell Pyroptosis to Enhance Therapeutic Efficacy Against Intervertebral Disc Degeneration

doi: 10.2147/JIR.S465690

Figure Lengend Snippet: Combined Score of Modified Formulations of LWDHD in Delaying IVDD

Article Snippet: Primary antibody against CASPASE1 was obtained from ProteinTech Group (Chicago, IL, USA).

Techniques: Modification, TUNEL Assay